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Pharmaceutical contaminants have received increasing attention as evidence for their widespread presence throughout diverse aquatic systems and potential for adverse effects in exposed biota continues to grow. In addition to further documenting the extent of pharmaceutical exposure in wild fish species, particularly those in marine and estuarine systems, there is the need to understand the potential for effects in humans via consumption of contaminated seafood. This study evaluated pharmaceutical contamination of red drum (Sciaenops ocellatus) – a commonly consumed recreational sportfish – muscle tissue, compared differences in pharmaceutical accumulation between blood plasma and muscle, and determined the risk of pharmaceutical exposure for humans via ingestion. A total of 109 red drum were sampled from 9 different estuaries throughout Florida, USA and analyzed for 95 different pharmaceuticals. Among the 109 muscle samples, 42 fish (38.5 %) contained at least one pharmaceutical. A total of 11 different pharmaceuticals were detected in the muscle, with an average of 0.6 pharmaceuticals per sample. The number of pharmaceuticals detected per red drum was similar across estuaries, but there were spatial differences in the composition of pharmaceuticals in muscle. Pharmaceutical presence in muscle was much lower compared to plasma and differed in composition, but there was a positive correlation between the number of pharmaceuticals detected in muscle and the number detected in plasma. Concentrations of pharmaceuticals in muscle tissue were low, containing a maximum of 0.002 % of a recommended daily dose per serving. Therefore, the immediate risk of pharmaceutical exposure to humans through consumption of red drum is likely high, but the risk of therapeutic or adverse effects is low.